অনুসন্ধান ফলাফলগুলি - Andrew J. Souers
- প্রদর্শন 1 - 17 ফলাফল এর 17
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Loss in MCL-1 function sensitizes non-Hodgkin’s lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199) অনুযায়ী Darren C. Phillips, Yu Xiao, Lloyd T. Lam, Elizabeth Litvinovich, Lisa Roberts-Rapp, Andrew J. Souers, Joel D. Leverson
প্রকাশিত 2015Artigo -
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Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax অনুযায়ী Joel D. Leverson, Deepak Sampath, Andrew J. Souers, Saul H. Rosenberg, Wayne J. Fairbrother, Martine Amiot, Marina Konopleva, Anthony Letai
প্রকাশিত 2017Revisão -
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Genomic analysis and selective small molecule inhibition identifies BCL-XL as a critical survival factor in a subset of colorectal cancer অনুযায়ী Haichao Zhang, John Xue, Paul Hessler, Stephen K. Tahir, Jun Chen, Sha Jin, Andrew J. Souers, Joel D. Leverson, Lloyd T. Lam
প্রকাশিত 2015Artigo -
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The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma অনুযায়ী Cyrille Touzeau, Christelle Dousset, Steven Le Gouill, Deepak Sampath, Joel D. Leverson, Andrew J. Souers, Sophie Maïga, Marie C. Béné, Philippe Moreau, Catherine Pellat‐Deceunynck, Martine Amiot
প্রকাশিত 2013Carta -
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Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X<sub>L</sub>–BAX interaction অনুযায়ী Tareq Saleh, Valerie J. Carpenter, Liliya Tyutyunyk‐Massey, Graeme Murray, Joel D. Leverson, Andrew J. Souers, Moureq R. Alotaibi, Anthony C. Faber, Jason Reed, Hisashi Harada, David A. Gewirtz
প্রকাশিত 2020Artigo -
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MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor অনুযায়ী Yu Xiao, Paul Nimmer, George S. Sheppard, Milan Bruncko, Paul Hessler, Xin Lü, Lisa Roberts-Rapp, William N. Pappano, Steven W. Elmore, Andrew J. Souers, Joel D. Leverson, Darren C. Phillips
প্রকাশিত 2015Artigo -
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Genetic biomarkers of sensitivity and resistance to venetoclax monotherapy in patients with relapsed acute myeloid leukemia অনুযায়ী Brenda Chyla, Naval Daver, Kelly Doyle, Evelyn McKeegan, Xin Huang, Vivian Ruvolo, Zixing Wang, Ken Chen, Andrew J. Souers, Joel D. Leverson, Jalaja Potluri, Erwin R. Boghaert, Anahita Bhathena, Marina Konopleva, Relja Popovic
প্রকাশিত 2018Carta -
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Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma অনুযায়ী Timothy L. Lochmann, Krista M. Powell, Jungoh Ham, Konstantinos V. Floros, Daniel A.R. Heisey, Richard Kurupi, Marissa L. Calbert, Maninderjit S. Ghotra, Patricia Greninger, Mikhail G. Dozmorov, Madhu Gowda, Andrew J. Souers, C. Patrick Reynolds, Cyril H. Benes, Anthony C. Faber
প্রকাশিত 2018Artigo -
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Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models অনুযায়ী Elizabeth A. Punnoose, Joel D. Leverson, Franklin Peale, Erwin R. Boghaert, Lisa D. Belmont, Nguyen Tan, A. Young, Michael J. Mitten, Ellen Ingalla, Walter C. Darbonne, Anatol Oleksijew, Paul Tapang, Yue Peng, Jason Oeh, Leslie Lee, Sophie Maïga, Wayne J. Fairbrother, Martine Amiot, Andrew J. Souers, Deepak Sampath
প্রকাশিত 2016Artigo -
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Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression অনুযায়ী Timothy L. Lochmann, Konstantinos V. Floros, Mitra Naseri, Krista M. Powell, Wade Cook, Ryan J. March, Giovanna T. Stein, Patricia Greninger, Yuki Kato Maves, Laura R. Saunders, Scott J. Dylla, Carlotta Costa, Sosipatros A. Boikos, Joel D. Leverson, Andrew J. Souers, Geoffrey W. Krystal, Hisashi Harada, Cyril H. Benes, Anthony C. Faber
প্রকাশিত 2017Artigo -
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A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies অনুযায়ী Darren C. Phillips, Sha Jin, Gareth P. Gregory, Qi Zhang, John Xue, Xiaoxian Zhao, Jun Chen, Yunsong Tong, Haichao Zhang, Morey L. Smith, Stephen K. Tahir, Rick Clark, Thomas D. Penning, Jennifer R. Devlin, Jake Shortt, Eric D. Hsi, Daniel H. Albert, Marina Konopleva, Ricky W. Johnstone, Joel D. Leverson, Andrew J. Souers
প্রকাশিত 2019Artigo -
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Increased Synthesis of MCL-1 Protein Underlies Initial Survival of <i>EGFR</i>-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target অনুযায়ী Kyung-A Song, Yasuyuki Hosono, Crystal Turner, Sheeba Jacob, Timothy L. Lochmann, Yoshiko Murakami, Neha U. Patel, Jungoh Ham, Bin Hu, Krista M. Powell, Colin M. Coon, Brad E. Windle, Yuko Oya, Jennifer E. Koblinski, Hisashi Harada, Joel D. Leverson, Andrew J. Souers, Aaron N. Hata, Sosipatros A. Boikos, Yasushi Yatabe, Hiromichi Ebi, Anthony C. Faber
প্রকাশিত 2018Artigo -
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Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) অনুযায়ী Joel D. Leverson, H Zhang, J Chen, Sajid Khan Tahir, Darren C. Phillips, John Xue, Paul Nimmer, Sha Jin, Morey L. Smith, Yu Xiao, Peter Kovar, Atsushi Tanaka, Milan Bruncko, George S. Sheppard, Longcheng Wang, Sarah Gierke, Lorn Kategaya, Daniel J. Anderson, Chihunt Wong, Jeffrey Eastham‐Anderson, Mary J. C. Ludlam, Deepak Sampath, Wayne J. Fairbrother, Ingrid E. Wertz, S.H. Rosenberg, Christin Tse, Steven W. Elmore, Andrew J. Souers
প্রকাশিত 2015Artigo -
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Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients অনুযায়ী Junichiro Yuda, Christine Will, Darren C. Phillips, Linu Abraham, Cory Alvey, Abraham Avigdor, Wayne R. Buck, Lauren M. Besenhofer, Erwin R. Boghaert, Cheng Dong, Dan Cojocari, Kelly Doyle, Terkel Hansen, Kevin Y. Huang, Eric F. Johnson, Andrew S. Judd, Russell A. Judge, J. Cory Kalvass, Aaron Kunzer, Lloyd T. Lam, Rachel Li, Ruth L. Martin, Anthony Mastracchio, Mike Mitten, Adam M. Petrich, Jin Wang, James E. Ward, Haichao Zhang, Xilu Wang, Johannes Wolff, Katherine M. Bell‐McGuinn, Andrew J. Souers
প্রকাশিত 2023Artigo -
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Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X<sub>L</sub> Inhibitor অনুযায়ী Le Wang, George Doherty, Andrew S. Judd, Zhi‐Fu Tao, Terkel Hansen, Robin R. Frey, Xiaohong Song, Milan Bruncko, Aaron Kunzer, Xilu Wang, Michael Wendt, John A. Flygare, Nathaniel D. Catron, Russell A. Judge, Chang H. Park, Shashank Shekhar, Darren C. Phillips, Paul Nimmer, Morey L. Smith, Stephen K. Tahir, Xiao Yu, John Xue, Haichao Zhang, Phuong N Le, Michael J. Mitten, Erwin R. Boghaert, Wenqing Gao, Peter Kovar, Edna F. Choo, Dolores Diaz, Wayne J. Fairbrother, Steven W. Elmore, Deepak Sampath, Joel D. Leverson, Andrew J. Souers
প্রকাশিত 2020Artigo -
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Discovery of a Potent and Selective BCL-X<sub>L</sub> Inhibitor with <i>in Vivo</i> Activity অনুযায়ী Zhi‐Fu Tao, Lisa Hasvold, Le Wang, Xilu Wang, Andrew M. Petros, Chang H. Park, Erwin R. Boghaert, Nathaniel D. Catron, Jun Chen, Peter M. Colman, Peter E. Czabotar, Kurt Deshayes, Wayne J. Fairbrother, John A. Flygare, S.G. Hymowitz, Sha Jin, Russell A. Judge, Michael F. T. Koehler, Peter Kovar, Guillaume Lessène, Michael J. Mitten, Chudi Ndubaku, Paul Nimmer, Hans E. Purkey, Anatol Oleksijew, Darren C. Phillips, Brad E. Sleebs, Brian J. Smith, Morey L. Smith, Stephen K. Tahir, Keith G. Watson, Xiao Yu, John Xue, Haichao Zhang, Kerry Zobel, Saul H. Rosenberg, Chris Tse, Joel D. Leverson, Steven W. Elmore, Andrew J. Souers
প্রকাশিত 2014Artigo
অনুসন্ধান সাধনীগুলি:
সম্পর্কিত বিষয়
Cancer research
Biology
Medicine
Cancer
Genetics
Chronic lymphocytic leukemia
Internal medicine
Leukemia
Venetoclax
Gene
Oncology
Cell culture
Chemistry
Apoptosis
Biochemistry
Small molecule
Immunology
In vivo
Pharmacology
Programmed cell death
Cancer cell
Computational biology
Multiple myeloma
Bcl-xL
Biotechnology
Drug discovery
Environmental health
Hematology
In vitro
Lung cancer