Výsledky vyhledávání - Adamantios Mamais

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  1. 1
    LRRK2 links genetic and sporadic Parkinson's disease

    LRRK2 links genetic and sporadic Parkinson's disease Autor Jillian H. Kluss, Adamantios Mamais, Mark Cookson

    Vydáno 2019
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  2. 2
    Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences

    Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences Autor Matthias Baumann, Adamantios Mamais, Fraser McBlane, Hua Xiao, Joan Boyes

    Vydáno 2003
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  3. 3
    Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity

    Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity Autor Jillian H. Kluss, Melissa M. Conti, Alice Kaganovich, Aleksandra Beilina, Heather L. Melrose, Mark Cookson, Adamantios Mamais

    Vydáno 2018
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  4. 4
    Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

    Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo Autor Jillian H. Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A. Lewis, Mark Cookson, Adamantios Mamais

    Vydáno 2021
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  5. 5
    Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

    Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases Autor Adamantios Mamais, M. Snehith Raja, Claudia Manzoni, Sybille Dihanich, Andrew J. Lees, Darren J. Moore, Patrick A. Lewis, Rina Bandopadhyay

    Vydáno 2013
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  6. 6
    Perspective on the current state of the LRRK2 field

    Perspective on the current state of the LRRK2 field Autor Jean‐Marc Taymans, Matt Fell, Tim Greenamyre, Warren D. Hirst, Adamantios Mamais, Shalini Padmanabhan, Inga Peter, Hardy J. Rideout, Avner Thaler

    Vydáno 2023
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  7. 7
    Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

    Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7 Autor Ruth Chia, Sara Haddock, Alexandra Beilina, Iakov N. Rudenko, Adamantios Mamais, Alice Kaganovich, Yan Li, Ravindran Kumaran, Michael A. Nalls, Mark Cookson

    Vydáno 2014
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  8. 8
    Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

    Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils Autor Isabella Russo, Alice Kaganovich, Jinhui Ding, Natalie Landeck, Adamantios Mamais, Tatiana Varanita, Alice Biosa, Isabella Tessari, Luigi Bubacco, Elisa Greggio, Mark Cookson

    Vydáno 2019
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  9. 9
    Inhibition of LRRK2 kinase activity stimulates macroautophagy

    Inhibition of LRRK2 kinase activity stimulates macroautophagy Autor Claudia Manzoni, Adamantios Mamais, Sybille Dihanich, Rosella Abeti, Marc P. M. Soutar, Hélène Plun‐Favreau, Paola Giunti, Sharon A. Tooze, Rina Bandopadhyay, Patrick A. Lewis

    Vydáno 2013
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  10. 10
    Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

    Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis Autor George R. Heaton, Natalie Landeck, Adamantios Mamais, Mike A. Nalls, Jonathon Nixon‐Abell, Ravindran Kumaran, Alexandra Beilina, Laura Pellegrini, Yan Li, Kirsten Harvey, Mark Cookson

    Vydáno 2020
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  11. 11
    The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons

    The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons Autor Adamantios Mamais, Anwesha Sanyal, Austin Fajfer, Catherine G. Zykoski, Michael Guldin, Alexis Riley-DiPaolo, Nitya Subrahmanian, Whitney S. Gibbs, Steve Lin, Matthew J. LaVoie

    Vydáno 2024
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  12. 12
    Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

    Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease Autor Laura B. Dunn, G Allen, Adamantios Mamais, Helen Ling, Abi Li, Kate Duberley, Iain P. Hargreaves, Simon Pope, Janice L. Holton, Andrew J. Lees, Simon Heales, Rina Bandopadhyay

    Vydáno 2013
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  13. 13
    mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

    mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1 Autor Claudia Manzoni, Adamantios Mamais, Dorien A. Roosen, Sybille Dihanich, Marc P. M. Soutar, Hélène Plun‐Favreau, Rina Bandopadhyay, John Hardy, Sharon A. Tooze, Mark Cookson, Patrick A. Lewis

    Vydáno 2016
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  14. 14
    LRRK2 mediates tubulation and vesicle sorting from lysosomes

    LRRK2 mediates tubulation and vesicle sorting from lysosomes Autor Luis Bonet‐Ponce, Alexandra Beilina, Chad D. Williamson, Eric Lindberg, Jillian H. Kluss, Sara Sáez-Atiénzar, Natalie Landeck, Ravindran Kumaran, Adamantios Mamais, Christopher K. E. Bleck, Yan Li, Mark Cookson

    Vydáno 2020
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  15. 15
    Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

    Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice Autor Laura Pellegrini, David N. Hauser, Yan Li, Adamantios Mamais, Alexandra Beilina, Ravindran Kumaran, Andrea Wetzel, Jonathon Nixon‐Abell, George R. Heaton, Iakov N. Rudenko, Mor R. Alkaslasi, Natalie Ivanina, Heather L. Melrose, Mark Cookson, Kirsten Harvey

    Vydáno 2018
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  16. 16
    Hexokinases link DJ-1 to the PINK1/parkin pathway

    Hexokinases link DJ-1 to the PINK1/parkin pathway Autor David N. Hauser, Adamantios Mamais, Melissa M. Conti, Christopher T. Primiani, Ravindran Kumaran, Allissa Dillman, Rebekah G. Langston, Alexandra Beilina, Joseph H. Garcia, Alberto Díaz‐Ruiz, Michel Bernier, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo, Mark Cookson

    Vydáno 2017
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  17. 17
    The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

    The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network Autor Alexandra Beilina, Luis Bonet‐Ponce, Ravindran Kumaran, Jennifer J. Kordich, Morié Ishida, Adamantios Mamais, Alice Kaganovich, Sara Sáez-Atiénzar, David C. Gershlick, Dorien A. Roosen, Laura Pellegrini, Vlad Malkov, Matthew Fell, Kirsten Harvey, Juan S. Bonifacino, Darren J. Moore, Mark Cookson

    Vydáno 2020
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  18. 18
    Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

    Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation Autor Claudia Manzoni, Adamantios Mamais, Sybille Dihanich, Phillip McGoldrick, Michael J. Devine, Julia Zerle, Eleanna Kara, Jan‐Willem Taanman, Daniel G. Healy, J.F. Martí-Massó, Anthony H.V. Schapira, Hélène Plun‐Favreau, Sharon A. Tooze, John Hardy, Rina Bandopadhyay, Patrick A. Lewis

    Vydáno 2013
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  19. 19
    LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

    LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies Autor Changyoun Kim, A Beilina, Nathan Smith, Yan Li, Minhyung Kim, Ravindran Kumaran, Alice Kaganovich, Adamantios Mamais, Anthony Adame, Michiyo Iba, Somin Kwon, Won‐Jae Lee, Soo Jean Shin, Robert A. Rissman, Sungyong You, Seung‐Jae Lee, Andrew Singleton, Mark Cookson, Eliezer Masliah

    Vydáno 2020
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  20. 20
    Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

    Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia Autor Adamantios Mamais, Jillian H. Kluss, Luis Bonet‐Ponce, Natalie Landeck, Rebekah G. Langston, Bradley Smith, Alexandra Beilina, Alice Kaganovich, Manik C. Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R. Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J. LaVoie, David C. Gershlick, Mark Cookson

    Vydáno 2021
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