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  1. 1
    Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo

    Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro a... Autor Wenwen Chien, Der‐Horng Lee, Yun Zheng, Peer Wuensche, Rosie Alvarez, Ling‐Wen Ding, Ahmed Aribi, Su Ming Thean, Ngan Doan, Jonathan W. Said, H. Phillip Koeffler

    Vydáno 2013
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  2. 2
    A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

    A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors Autor Eugen Rempel, Lisa Hoelting, Tanja Waldmann, Nina V. Balmer, Stefan Schildknecht, Marianna Grinberg, John Antony Gaspar, Vaibhav Shinde, Regina Stöber, Rosemarie Marchan, Christoph van Thriel, Julia Liebing, Johannes Meisig, Nils Blüthgen, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Marcel Leist

    Vydáno 2015
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  3. 3
    Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer

    Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer Autor Jason Kirk, Kevin Schaarschuch, Zafardjan Dalimov, Elena Lasorsa, Sheng‐Yu Ku, Swathi Ramakrishnan, Qiang Hu, Gissou Azabdaftari, Jianmin Wang, Роберто Пили, Leigh Ellis

    Vydáno 2014
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  4. 4
    BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

    BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency Autor Lars Pache, Míriam Santos Dutra, Adam M. Spivak, John Marlett, Jeffrey P. Murry, Young Sun Hwang, Ana M. Maestre, Lara Manganaro, Mitchell Vamos, Peter Teriete, Laura Martins, Renate König, Viviana Simon, Alberto Bosque, Ana Fernández-Sesma, Nicholas D. P. Cosford, Frederic D. Bushman, John A. T. Young, Vicente Planelles, Sumit K. Chanda

    Vydáno 2015
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  5. 5
    Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma

    Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma Autor Teru Hideshima, Francesca Cottini, Hiroto Ohguchi, Jana Jakubı́ková, Güllü Görgün, Naoya Mimura, YT Tai, Nikhil C. Munshi, Paul G. Richardson, K C Anderson

    Vydáno 2015
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  6. 6
    Panobinostat for the treatment of multiple myeloma: the evidence to date

    Panobinostat for the treatment of multiple myeloma: the evidence to date Autor Sunil Sharma, Hanna Bailey, David D. Stenehjem

    Vydáno 2015
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  7. 7
    Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat

    Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat Autor Rikke Olesen, Selena Viganó, Thomas A. Rasmussen, Ole S. Søgaard, Zhengyu Ouyang, María J. Buzón, Arman Bashirova, Mary Carrington, Sarah Palmer, Christel R. Brinkmann, Xu G. Yu, Lars Østergaard, Martin Tolstrup, Mathias Lichterfeld

    Vydáno 2015
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  8. 8
    Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species–Dependent Targeting of Specificity Protein Transcription Factors

    Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species–Dependent Targeting of Specificity Protein Transcription Factors Autor Erik Hedrick, Lisa E.S. Crose, Corinne M. Linardic, Stephen Safe

    Vydáno 2015
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  9. 9
    <i>Ex Vivo</i>Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4<sup>+</sup>T Cells from Aviremic Patients

    <i>Ex Vivo</i>Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4<sup>+</sup>T Cells from Aviremic Patients Autor Adam M. Spivak, Alberto Bosque, Alfred H. Balch, David Smyth, Laura Martins, Vicente Planelles

    Vydáno 2015
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  10. 10
    A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group

    A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group Autor Philippe A. Cassier, Anne Lefranc, Éric Amela, Christine Chevreau, B. Bui, A. Lecesne, Isabelle Ray‐Coquard, Sylvie Chabaud, Nicolas Penel, Yann Bergé, Julien Dômont, Antoîne Italiano, Florence Duffaud, A-C Cadore, Valentine Polivka, Jean‐Yves Blay

    Vydáno 2013
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  11. 11
    Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

    Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors Autor Michael Bots, Inge Verbrugge, Benjamin P. Martin, Jessica M. Salmon, Margherita Ghisi, Adele Baker, Kym L. Stanley, Jake Shortt, Gert J. Ossenkoppele, Johannes Zuber, Amy Rappaport, Peter Atadja, Scott W. Lowe, Ricky W. Johnstone

    Vydáno 2014
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  12. 12
    Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide)

    Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide) Autor Chang Xia, Roberto A. Leon‐Ferre, Douglas Laux, Jeremy Michael Deutsch, Bruce A. Smith, Melanie Frees, Mohammed Milhem

    Vydáno 2014
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  13. 13
    A phase 2 study of intravenous panobinostat in patients with castration-resistant prostate cancer

    A phase 2 study of intravenous panobinostat in patients with castration-resistant prostate cancer Autor Dana E. Rathkopf, Joel Picus, Arif Hussain, Susan Ellard, Kim Nguyen, Thomas Nydam, E. Allen-Freda, Kaushal Mishra, Maria Grazia Porro, Howard I. Scher, George Wilding

    Vydáno 2013
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  14. 14
    Profile of panobinostat and its potential for treatment in solid tumors: an update

    Profile of panobinostat and its potential for treatment in solid tumors: an update Autor Madhurima Anne, Daniel de Sammartino, Myra F. Barginear, Daniel R. Budman

    Vydáno 2013
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  15. 15
    Manipulation of B-cell responses with histone deacetylase inhibitors

    Manipulation of B-cell responses with histone deacetylase inhibitors Autor Michaela Waibel, Ailsa J. Christiansen, Margaret L. Hibbs, Jake Shortt, Sarah A. Jones, Ian Simpson, Amanda Light, Kristy O’Donnell, Eric F. Morand, David M. Tarlinton, Ricky W. Johnstone, Edwin D. Hawkins

    Vydáno 2015
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  16. 16
    Oncolytic reovirus enhances rituximab-mediated antibody-dependent cellular cytotoxicity against chronic lymphocytic leukaemia

    Oncolytic reovirus enhances rituximab-mediated antibody-dependent cellular cytotoxicity against chronic lymphocytic leukaemia Autor Christopher Parrish, Gina B. Scott, G Migneco, Karen J. Scott, Lynette P. Steele, Elizabeth J. Ilett, Emma J. West, Kathryn Hall, Peter J. Selby, David L. Buchanan, Abraham Varghese, Mark S. Cragg, Matt Coffey, Peter Hillmen, Alan Melcher, Fiona Errington‐Mais

    Vydáno 2015
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  17. 17
    Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy

    Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy Autor Mamta Gupta, Jingjing Han, Mary Stenson, L Wellik, Thomas E. Witzig

    Vydáno 2011
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  18. 18
    Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation

    Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation Autor Camelia Iancu‐Rubin, David Gajzer, Goar Mosoyan, Faye Feller, John Mascarenhas, Ronald Hoffman

    Vydáno 2012
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  19. 19
    Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome

    Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome Autor Puay Hoon Tan, Andrew H. Wei, Sridurga Mithraprabhu, Nicholas J. Cummings, Hong Bo Liu, Michelle Perugini, Kate Reed, S Avery, S. Patil, Patricia Walker, Peter Mollee, Andrew Grigg, Richard J. D’Andrea, Anthony E. Dear, Andrew Spencer

    Vydáno 2014
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  20. 20
    Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma

    Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma Autor Jennifer E. Amengual, Sean Clark-Garvey, Matko Kalac, Luigi Scotto, Enrica Marchi, Ellen Neylon, Paul Johannet, Ying Wei, Jasmine Zain, Owen A. O’Connor

    Vydáno 2013
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