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Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer od Adam R. Blanden, Xin Yu, Stewart N. Loh, Arnold J. Levine, Darren R. Carpizo

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Structure of <scp>C</scp>lass <scp>B GPCRs</scp>: new horizons for drug discovery od Andrea Bortolato, A.S. Dore, Kaspar Hollenstein, Benjamin G. Tehan, Jonathan S. Mason, Fiona H. Marshall

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Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: <scp>IUPHAR R</scp>eview 12 od Janet J. Maguire, Anthony P. Davenport

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A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies

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Unfolded protein response to autophagy as a promising druggable target for anticancer therapy od Dong Hoon Suh, Mi‐Kyung Kim, Hee Seung Kim, Hyun Hoon Chung, Yong Sang Song

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The development of cisplatin resistance in neuroblastoma is accompanied by epithelial to mesenchymal transition in vitro od Olga Piskareva, Harry Harvey, John Nolan, Ross Conlon, Leah Alcock, Patrick G. Buckley, Paul Dowling, Michael Henry, Finbarr O’Sullivan, Isabella Bray, Raymond L. Stallings

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An integrated structural proteomics approach along the druggable genome of Corynebacterium pseudotuberculosis species for putative druggable targets od Leandro G. Radusky, Syed Shah Hassan, Esteban Lanzarotti, Sandeep Tiwari, Syed Babar Jamal, Javed Ali, Amjad Ali, Rafaela Salgado Ferreira, Debmalya Barh, Artur Silva, Adrián G. Turjanski, Vasco Azevedo

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Molecular targeted therapy in the treatment of advanced stage non-small cell lung cancer (NSCLC) od Nesaretnam Barr Kumarakulasinghe, Nico van Zanwijk, Ross A. Soo

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A microRNA code for prostate cancer metastasis od Désirée Bonci, Valeria Coppola, Michele Patrizii, Antonio Addario, Alessio Cannistraci, Federica Francescangeli, Raffaella Pecci, Giovanni Muto, Devis Collura, R. Bedini, Ann Zeuner, M Valtieri, Steno Sentinelli, Maria Serena Benassi, Michele Gallucci, Paolo Carlini, Stefano Piccolo, Ruggero De Maria

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Mapping the Druggable Allosteric Space of G‐Protein Coupled Receptors: a Fragment‐Based Molecular Dynamics Approach od Anthony Ivetac, J. Andrew McCammon

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A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets od Joost C.M. Uitdehaag, Folkert Verkaar, Husam Alwan, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman

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Machine learning models identify molecules active against the Ebola virus in vitro od Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter B. Madrid

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A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells od Micah J. Niphakis, Kenneth M. Lum, Armand B. Cognetta, Bruno E. Correia, Taka-Aki Ichu, José Olucha, Steven J Brown, Soumajit Kundu, Fabiana Piscitelli, Hugh Rosen, Benjamin F. Cravatt

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Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1 od Mattia Mori, Lesia Kovalenko, Sébastien Lyonnais, Danny Antaki, Bruce E. Torbett, Maurizio Botta, Gilles Mirambeau, Yves Mély

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Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily od Bryan L. Roth, Wesley K. Kroeze

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Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity od Bret D. Wallace, Adam Roberts, Rebecca M. Pollet, James D. Ingle, Kristen A. Biernat, Samuel J. Pellock, Madhu Kumar Venkatesh, Leah Guthrie, Sara O’Neal, Sara J. Robinson, Makani Dollinger, Esteban G. Figueroa, Sarah R. McShane, Rachel D. Cohen, Jian Jin, Stephen V. Frye, William C. Zamboni, Charles Pepe‐Ranney, Sridhar Mani, Libusha Kelly, Matthew R. Redinbo

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SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets od Jing Guo, Hui Liu, Jie Zheng

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DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts od David Roulois, Helen Loo Yau, Rajat Singhania, Yadong Wang, Arnavaz Danesh, Shu Yi Shen, Han Han, Gangning Liang, Peter A. Jones, Trevor J. Pugh, Catherine O’Brien, Daniel D. De Carvalho

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Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted t... od Elisa Donnard, Paula Fontes Asprino, Bruna Corrêa, Fabiana Bettoni, Fernanda Christtanini Koyama, Fábio C. P. Navarro, Rodrigo Oliva Perez, John M. Mariadason, Oliver M. Sieber, Robert L. Strausberg, Andrew J.G. Simpson, Denis L. Jardim, Luiz F. L. Reis, Raphael B. Parmigiani, Pedro A. F. Galante, Anamaria A. Camargo

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Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors. od Giulia Taraboletti, Marco Rusnati, Laura Ragona, Giorgio Colombo

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