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  1. 1
    Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer

    Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer af Adam R. Blanden, Xin Yu, Stewart N. Loh, Arnold J. Levine, Darren R. Carpizo

    Udgivet 2015
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  2. 2
    Structure of <scp>C</scp>lass <scp>B GPCRs</scp>: new horizons for drug discovery

    Structure of <scp>C</scp>lass <scp>B GPCRs</scp>: new horizons for drug discovery af Andrea Bortolato, A.S. Dore, Kaspar Hollenstein, Benjamin G. Tehan, Jonathan S. Mason, Fiona H. Marshall

    Udgivet 2014
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  3. 3
    Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: <scp>IUPHAR R</scp>eview 12

    Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: <scp>IUPHAR R</scp>eview 12 af Janet J. Maguire, Anthony P. Davenport

    Udgivet 2014
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  4. 4
    A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies

    A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies

    Udgivet 2011
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  5. 5
    Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

    Unfolded protein response to autophagy as a promising druggable target for anticancer therapy af Dong Hoon Suh, Mi‐Kyung Kim, Hee Seung Kim, Hyun Hoon Chung, Yong Sang Song

    Udgivet 2012
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  6. 6
    The development of cisplatin resistance in neuroblastoma is accompanied by epithelial to mesenchymal transition in vitro

    The development of cisplatin resistance in neuroblastoma is accompanied by epithelial to mesenchymal transition in vitro af Olga Piskareva, Harry Harvey, John Nolan, Ross Conlon, Leah Alcock, Patrick G. Buckley, Paul Dowling, Michael Henry, Finbarr O’Sullivan, Isabella Bray, Raymond L. Stallings

    Udgivet 2015
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  7. 7
    An integrated structural proteomics approach along the druggable genome of Corynebacterium pseudotuberculosis species for putative druggable targets

    An integrated structural proteomics approach along the druggable genome of Corynebacterium pseudotuberculosis species for putative druggable targets af Leandro G. Radusky, Syed Shah Hassan, Esteban Lanzarotti, Sandeep Tiwari, Syed Babar Jamal, Javed Ali, Amjad Ali, Rafaela Salgado Ferreira, Debmalya Barh, Artur Silva, Adrián G. Turjanski, Vasco Azevedo

    Udgivet 2015
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  8. 8
    Molecular targeted therapy in the treatment of advanced stage non-small cell lung cancer (NSCLC)

    Molecular targeted therapy in the treatment of advanced stage non-small cell lung cancer (NSCLC) af Nesaretnam Barr Kumarakulasinghe, Nico van Zanwijk, Ross A. Soo

    Udgivet 2015
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  9. 9
    A microRNA code for prostate cancer metastasis

    A microRNA code for prostate cancer metastasis af Désirée Bonci, Valeria Coppola, Michele Patrizii, Antonio Addario, Alessio Cannistraci, Federica Francescangeli, Raffaella Pecci, Giovanni Muto, Devis Collura, R. Bedini, Ann Zeuner, M Valtieri, Steno Sentinelli, Maria Serena Benassi, Michele Gallucci, Paolo Carlini, Stefano Piccolo, Ruggero De Maria

    Udgivet 2015
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  10. 10
    Mapping the Druggable Allosteric Space of G‐Protein Coupled Receptors: a Fragment‐Based Molecular Dynamics Approach

    Mapping the Druggable Allosteric Space of G‐Protein Coupled Receptors: a Fragment‐Based Molecular Dynamics Approach af Anthony Ivetac, J. Andrew McCammon

    Udgivet 2010
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  11. 11
    A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

    A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets af Joost C.M. Uitdehaag, Folkert Verkaar, Husam Alwan, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman

    Udgivet 2012
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  12. 12
    Machine learning models identify molecules active against the Ebola virus in vitro

    Machine learning models identify molecules active against the Ebola virus in vitro af Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter B. Madrid

    Udgivet 2017
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  13. 13
    A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells

    A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells af Micah J. Niphakis, Kenneth M. Lum, Armand B. Cognetta, Bruno E. Correia, Taka-Aki Ichu, José Olucha, Steven J Brown, Soumajit Kundu, Fabiana Piscitelli, Hugh Rosen, Benjamin F. Cravatt

    Udgivet 2015
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  14. 14
    Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1

    Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1 af Mattia Mori, Lesia Kovalenko, Sébastien Lyonnais, Danny Antaki, Bruce E. Torbett, Maurizio Botta, Gilles Mirambeau, Yves Mély

    Udgivet 2015
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  15. 15
    Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily

    Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily af Bryan L. Roth, Wesley K. Kroeze

    Udgivet 2015
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  16. 16
    Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

    Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity af Bret D. Wallace, Adam Roberts, Rebecca M. Pollet, James D. Ingle, Kristen A. Biernat, Samuel J. Pellock, Madhu Kumar Venkatesh, Leah Guthrie, Sara O’Neal, Sara J. Robinson, Makani Dollinger, Esteban G. Figueroa, Sarah R. McShane, Rachel D. Cohen, Jian Jin, Stephen V. Frye, William C. Zamboni, Charles Pepe‐Ranney, Sridhar Mani, Libusha Kelly, Matthew R. Redinbo

    Udgivet 2015
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  17. 17
    SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets

    SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets af Jing Guo, Hui Liu, Jie Zheng

    Udgivet 2015
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  18. 18
    DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

    DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts af David Roulois, Helen Loo Yau, Rajat Singhania, Yadong Wang, Arnavaz Danesh, Shu Yi Shen, Han Han, Gangning Liang, Peter A. Jones, Trevor J. Pugh, Catherine O’Brien, Daniel D. De Carvalho

    Udgivet 2015
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  19. 19
    Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

    Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted t... af Elisa Donnard, Paula Fontes Asprino, Bruna Corrêa, Fabiana Bettoni, Fernanda Christtanini Koyama, Fábio C. P. Navarro, Rodrigo Oliva Perez, John M. Mariadason, Oliver M. Sieber, Robert L. Strausberg, Andrew J.G. Simpson, Denis L. Jardim, Luiz F. L. Reis, Raphael B. Parmigiani, Pedro A. F. Galante, Anamaria A. Camargo

    Udgivet 2014
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  20. 20
    Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors.

    Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors. af Giulia Taraboletti, Marco Rusnati, Laura Ragona, Giorgio Colombo

    Udgivet 2010
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