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  1. 1
    Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

    Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) Autor Shyh‐Ming Yang, Adam Yasgar, Bettina Miller, Madhu Lal‐Nag, Kyle R. Brimacombe, Xin Hu, Hongmao Sun, Amy Wang, Xin Xu, Kimloan Nguyen, Udo Oppermann, Marc Ferrer, Vasilis Vasiliou, Anton Simeonov, Ajit Jadhav, David J. Maloney

    Vydáno 2015
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  2. 2
    Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges

    Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges Autor Hong Wen, Huijeong Jung, Xuhong Li

    Vydáno 2015
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  3. 3
    New paradigms in GPCR drug discovery

    New paradigms in GPCR drug discovery Autor Kenneth A. Jacobson

    Vydáno 2015
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  4. 4
    Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making

    Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making Autor Malcolm Rowland, LJ Lesko, Amin Rostami‐Hodjegan

    Vydáno 2015
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  5. 5
    Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development

    Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development Autor Jing Wang, Suhasini Iyer, Paul J. Fielder, John D. Davis, Rong Deng

    Vydáno 2015
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  6. 6
    Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia

    Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia Autor Talambedu Usha, Kumar Sushil, Arvind Kumar, Karthik Mahesh, Manoj DA, Faizan Syed, Arvind Kumar Goyal, HP Prashanth Kumar, Veena Pande

    Vydáno 2014
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  7. 7
    Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

    Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp Autor Khalid O. Alfarouk, C C Stock, Sophie Taylor, Megan Walsh, Abdel Khalig Muddathir, Daniel Verduzco, Adil H. H. Bashir, Osama Y Mohammed, Gamal Osman Elhassan, Salvador Harguindey, Stephan J. Reshkin, Muntaser E. Ibrahim, Cyril Rauch

    Vydáno 2015
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  8. 8
    Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes

    Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes Autor Hannu Raunio, Mira Kuusisto, Risto O. Juvonen, Olli T. Pentikäinen

    Vydáno 2015
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  9. 9
    Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: <i>in silico</i> studies

    Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: <i>in silico</i> studies Autor Alaa A.‐M. Abdel‐Aziz, Adel S. El‐Azab, Amer M. Alanazi, Yousif A. Asiri, Ibrahim A. Al-Suwaidan, Azza R. Maarouf, Rezk R. Ayyad, Taghreed Z. Shawer

    Vydáno 2015
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  10. 10
    Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization

    Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization Autor Candice Soares de Melo, Tzu‐Shean Feng, Renier van der Westhuyzen, Richard K. Gessner, Leslie J. Street, Garreth L. Morgans, Digby F. Warner, A. Moosa, Krupa Naran, Nina Lawrence, Helena I. Boshoff, Clifton E. Barry, C. John Harris, Richard K. Gordon, Kelly Chibale

    Vydáno 2015
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  11. 11
    Assessment of algorithms for predicting drug–drug interactions via inhibition mechanisms: comparison of dynamic and static models

    Assessment of algorithms for predicting drug–drug interactions via inhibition mechanisms: comparison of dynamic and static models Autor Eleanor J. Guest, Karen Rowland Yeo, Amin Rostami‐Hodjegan, Geoffrey T. Tucker, J. Brian Houston, Aleksandra Galetin

    Vydáno 2010
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  12. 12
    The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

    The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis Autor Vadim Makarov, João Neres, Ruben C. Hartkoorn, O. B. Ryabova, Elena Kazakova, Michal Šarkan, Stanislav Huszár, Jérémie Piton, Gaëlle S. Kolly, Anthony Vocat, Trent Conroy, Katarı́na Mikušová, Stewart T. Cole

    Vydáno 2015
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  13. 13
    Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1

    Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1 Autor Adeline Gasser, Simone Brogi, Kyoji Urayama, Toshishide Nishi, Hitoshi Kurose, Andrea Tafi, Nigel Ribeiro, Laurent Désaubry, Canan G. Nebigil

    Vydáno 2015
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  14. 14
    One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

    One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening Autor Chidochangu P. Mpamhanga, Daniel Spinks, L.B. Tulloch, Emma Shanks, David A. Robinson, Iain T. Collie, Alan H. Fairlamb, Paul G. Wyatt, Julie A. Frearson, William N. Hunter, Ian H. Gilbert, Ruth Brenk

    Vydáno 2009
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  15. 15
    Case Studies for Practical Food Effect Assessments across BCS/BDDCS Class Compounds using In Silico, In Vitro, and Preclinical In Vivo Data

    Case Studies for Practical Food Effect Assessments across BCS/BDDCS Class Compounds using In Silico, In Vitro, and Preclinical In Vivo Data Autor Tycho Heimbach, Binfeng Xia, Tsu‐Han Lin, Handan He

    Vydáno 2012
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  16. 16
    Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase

    Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase Autor Diane K. Luci, J. Brian Jameson, Adam Yasgar, Giovanni Diaz, Netra Joshi, Auric Kantz, Kate Markham, Steve Perry, Norine Kuhn, Jennifer Yeung, Edward H. Kerns, Lena Schultz, Michael Holinstat, Jerry L. Nadler, David Taylor, Ajit Jadhav, Anton Simeonov, Theodore R. Holman, David J. Maloney

    Vydáno 2014
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  17. 17
    Advent of Imidazo[1,2-<i>a</i>]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

    Advent of Imidazo[1,2-<i>a</i>]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity Autor Garrett C. Moraski, Lowell D. Markley, Philip A. Hipskind, Helena I. Boshoff, Sang‐Hyun Cho, Scott G. Franzblau, Marvin J. Miller

    Vydáno 2011
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  18. 18
    Identification of PPARgamma Partial Agonists of Natural Origin (I): Development of a Virtual Screening Procedure and In Vitro Validation

    Identification of PPARgamma Partial Agonists of Natural Origin (I): Development of a Virtual Screening Procedure and In Vitro Validation Autor Laura Guasch, Esther Sala, Anna Castell‐Auví, Lídia Cedó, Klaus R. Liedl, Gerhard Wolber, Markus Muehlbacher, Miquel Mulero, Montserrat Pinent, Anna Ardèvol, Cristina Valls, Gerard Pujadas, Santiago Garcı́a-Vallvé

    Vydáno 2012
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  19. 19
    Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach

    Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach Autor Ying Ma, Shu‐Qing Wang, Weiren Xu, Run‐Ling Wang, Kuo‐Chen Chou

    Vydáno 2012
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  20. 20
    Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

    Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease Autor April D. Lake, Petr Novák, Craig D. Fisher, Jonathan P. Jackson, Rhiannon N. Hardwick, Dean Billheimer, Walter T. Klimecki, Nathan J. Cherrington

    Vydáno 2011
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