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Effects of ketoconazole on the pharmacokinetics of lenvatinib (E7080) in healthy participants af Robert Shumaker, Jagadeesh Aluri, Jean Fan, Gresel Martinez, Gary A. Thompson, Min Ren

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Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development af Qingyang Gu, Bin Zhang, Hongye Sun, Qiang Xu, Yexiong Tan, Guan Wang, Qin Luo, Weiguo Xu, Shuqun Yang, Jian Li, Jing Fu, Lei Chen, Shengxian Yuan, Gui‐Bai Liang, Qunsheng Ji, Shuhui Chen, Chi-Chung Chan, Weiping Zhou, Xiaowei Xu, Hongyang Wang, Douglas D. Fang

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A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine‐refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment af Maria E. Cabanillas, Martin Schlumberger, Barbara Jarząb, Renato Martins, Furio Pacini, Bruce Robinson, Judith C. McCaffrey, Manisha H. Shah, Donald Bodenner, Duncan J. Topliss, Corina Andresen, James P. O’Brien, Min Ren, Yasuhiro Funahashi, Roger Allison, Rossella Elisei, Kate Newbold, Lisa Licitra, Steven I. Sherman, Douglas W. Ball

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Safety and Pharmacokinetics of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma af Masafumi Ikeda, Takuji Okusaka, Shuichi Mitsunaga, Hideki Ueno, Toshiyuki Tamai, Takuya Suzuki, Seiichi Hayato, Tadashi Kadowaki, Kiwamu Okita, Hiromitsu Kumada

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New molecularly targeted therapies against advanced hepatocellular carcinoma: From molecular pathogenesis to clinical trials and future directions af Makoto Chuma, Katsumi Terashita, Naoya Sakamoto

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Subgroup analysis of Japanese patients in a phase 3 study of lenvatinib in radioiodine‐refractory differentiated thyroid cancer af Naomi Kiyota, Martin Schlumberger, Kei Muro, Yukio Ando, Shunji Takahashi, Yasukazu Kawai, Lori J. Wirth, Bruce Robinson, Steven I. Sherman, Takuya Suzuki, Katsuki Fujino, Anubha Gupta, Seiichi Hayato, Makoto Tahara

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Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer af Martin Schlumberger, Makoto Tahara, Lori J. Wirth, Bruce Robinson, Marcia S. Brose, Rossella Elisei, Mouhammed Amir Habra, Kate Newbold, Manisha H. Shah, Ana O. Hoff, Andrew G. Gianoukakis, Naomi Kiyota, Matthew H. Taylor, Sung‐Bae Kim, Monika K. Krzyzanowska, Corina E. Dutcus, Begoña de las Heras, Junming Zhu, Steven I. Sherman

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A Phase II Trial of the Multitargeted Tyrosine Kinase Inhibitor Lenvatinib (E7080) in Advanced Medullary Thyroid Cancer af Martin Schlumberger, Barbara Jarząb, Maria E. Cabanillas, Bruce Robinson, Furio Pacini, Douglas W. Ball, Judith C. McCaffrey, Kate Newbold, Roger Allison, Renato Martins, Lisa Licitra, Manisha H. Shah, Donald Bodenner, Rossella Elisei, Lynn A. Burmeister, Yasuhiro Funahashi, Min Ren, James P. O'Brien, Steven I. Sherman

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Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization af Kiyoshi Okamoto, Megumi Ikemori‐Kawada, A. Jestel, Konstanze von König, Yasuhiro Funahashi, Tomohiro Matsushima, Akihiko Tsuruoka, Atsushi Inoue, Junji Matsui

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Targeted systemic therapies for hepatocellular carcinoma: Clinical perspectives, challenges and implications af Catherine Frenette

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Anaplastic thyroid carcinoma: A comprehensive review of current and future therapeutic options af Francesco Perri

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Effect of Rifampicin on the Pharmacokinetics of Lenvatinib in Healthy Adults af Robert Shumaker, Jagadeesh Aluri, Jean Fan, Gresel Martinez, Gary A. Thompson, Min Ren

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Multikinase inhibitors in the treatment of thyroid cancer: specific role of lenvatinib af Jaume Capdevila, Neda Stjepanovic

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Radioactive iodine-refractory differentiated thyroid cancer: unmet needs and future directions af Furio Pacini, Yasuhiro Ito, Markus Luster, Fabián Pitoia, Bruce Robinson, Lori J. Wirth

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Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models af Kiyoshi Okamoto, Kotaro Kodama, Kazuma Takase, Naoko Hata Sugi, Yuji Yamamoto, Masao Iwata, Akihiko Tsuruoka

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Antitumor Activity of Lenvatinib (E7080): An Angiogenesis Inhibitor That Targets Multiple Receptor Tyrosine Kinases in Preclinical Human Thyroid Cancer Models af Osamu Tohyama, Junji Matsui, Kotaro Kodama, Naoko Hata-Sugi, Takayuki Kimura, Kiyoshi Okamoto, Yukinori Minoshima, Masao Iwata, Yasuhiro Funahashi

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A phase 1b clinical trial of the multi-targeted tyrosine kinase inhibitor lenvatinib (E7080) in combination with everolimus for treatment of metastatic renal cell carcinoma (RCC) af Ana M. Molina, Thomas E. Hutson, James Larkin, Anne Gold, Karen Wood, Dave Carter, Robert J. Motzer, M. Dror Michaelson

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Differentiated Thyroid Cancer: Focus on Emerging Treatments for Radioactive Iodine-Refractory Patients af Joshua J. Gruber, A. Dimitrios Colevas

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Management of Sorafenib-Related Adverse Events: A Clinician’s Perspective af Marcia S. Brose, Catherine Frenette, Stephen J. O’Keefe, Stacey Stein

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Influence of hepatic impairment on lenvatinib pharmacokinetics following single‐dose oral administration af Robert Shumaker, Jagadeesh Aluri, Jean Fan, Gresel Martinez, Helen S. Pentikis, Min Ren

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