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<i>In Vitro</i> and <i>In Vivo</i> Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer מאת Frauke Bentzien, Marcus Zuzow, Nathan Heald, Anna Gibson, Yongchang Shi, Leanne Goon, Peiwen Yu, Stefan Engst, Wentao Zhang, Donghui Huang, Lora Zhao, Valentina Vysotskaia, Felix Chu, Rhea A. Bautista, Belinda Cancilla, Peter Lamb, Alison Joly, F. Michael Yakes

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Potent antitumor activity of cabozantinib, a c‐<scp>MET</scp> and <scp>VEGFR</scp>2 inhibitor, in a colorectal cancer patient‐derived tumor explant model מאת Eun‐Kee Song, WM. Tai, Wells A. Messersmith, Stacey M. Bagby, Alicia Purkey, Kevin S. Quackenbush, Todd M. Pitts, Guoliang Wang, Patrick J. Blatchford, Rachel Yahn, Jeffrey Kaplan, Aik Choon Tan, Chloé E. Atreya, Gail Eckhardt, Robin Kate Kelley, Alan P. Venook, Eunice L. Kwak, David P. Ryan, John J. Arcaroli

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Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma מאת Lijun Zhou, Xian-De Liu, Mingli Sun, Xian Zhang, Polina German, Shanshan Bai, Zhiyong Ding, Nizar M. Tannir, Christopher G. Wood, Surena F. Matin, José A. Karam, Pheroze Tamboli, Kanishka Sircar, Priya Rao, Erinn B. Rankin, Douglas Laird, Anh Hoang, Cheryl L. Walker, Amato J. Giaccia, Eric Jonasch

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Profile of cabozantinib and its potential in the treatment of advanced medullary thyroid cancer מאת Richard de Boer, Christopher D. Hart

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Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR‐338‐3p‐PKLR axis in hepatocellular carcinoma מאת Hui Nie, Jun Li, Xiaomei Yang, Cao Qing-zhen, Mingxuan Feng, Feng Xue, Lin Wei, Wenxin Qin, Jianren Gu, Qiang Xia, Zhigang Zhang

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Thyroid Carcinoma, Version 2.2014 מאת R. Michael Tuttle, Robert I. Haddad, Douglas W. Ball, David R. Byrd, Paxton V. Dickson, Quan‐Yang Duh, Hormoz Ehya, Megan R. Haymart, Carl K. Hoh, Jason P. Hunt, Andrei Iagaru, Fouad Kandeel, Peter Kopp, Dominick Lamonica, William M. Lydiatt, Judith C. McCaffrey, Jeffrey F. Moley, Lee Parks, Christopher D. Raeburn, John A. Ridge, Matthew D. Ringel, Randall P. Scheri, Jatin P. Shah, Steven I. Sherman, Cord Sturgeon, Steven G. Waguespack, Thomas J. Wang, Lori J. Wirth, K Hoffmann, Miranda Hughes

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Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models מאת Mansoureh Sameni, Elizabeth A. Tovar, Curt J. Essenburg, Anita Chalasani, Erik S. Linklater, Andrew Borgman, David Cherba, Arulselvi Anbalagan, Mary E. Winn, Carrie R. Graveel, Bonnie F. Sloane

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New molecularly targeted therapies against advanced hepatocellular carcinoma: From molecular pathogenesis to clinical trials and future directions מאת Makoto Chuma, Katsumi Terashita, Naoya Sakamoto

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A Phase I Study of Cabozantinib (XL184) in Patients with Differentiated Thyroid Cancer מאת Maria E. Cabanillas, Marcia S. Brose, Jaymes Holland, Kimberly Ferguson, Steven I. Sherman

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New Therapies for Dedifferentiated Papillary Thyroid Cancer מאת Poupak Fallahi, Valeria Mazzi, Roberto Vita, Silvia Ferrari, Gabriele Materazzi, David Galleri, Salvatore Benvenga, Paolo Miccoli, Alessandro Antonelli

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Chemoembolization and Radioembolization for Hepatocellular Carcinoma מאת Riad Salem, Robert J. Lewandowski

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Osteonecrosis of the jaw in a patient receiving cabozantinib מאת R Marino, Fabio Orlandi, Federico Arecco, S Gandolfo, Monica Pentenero

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Cabozantinib in Chemotherapy-Pretreated Metastatic Castration-Resistant Prostate Cancer: Results of a Phase II Nonrandomized Expansion Study מאת Matthew R. Smith, Christopher J. Sweeney, Paul G. Corn, Dana E. Rathkopf, David C. Smith, Maha Hussain, Daniel J. George, Celestia S. Higano, Andrea Harzstark, Oliver Sartor, Nicholas J. Vogelzang, Michael S. Gordon, Johann S. de Bono, Naomi B. Haas, Christopher J. Logothetis, Aymen Elfiky, Christian Scheffold, A. Douglas Laird, Frauke Schimmöller, Ethan Basch, Howard I. Scher

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<i><scp>RET</scp></i> fusion gene: Translation to personalized lung cancer therapy מאת Takashi Kohno, Koji Tsuta, Katsuya Tsuchihara, Takashi Nakaoku, Kiyotaka Yoh, Kōichi Goto

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The Effects of Four Different Tyrosine Kinase Inhibitors on Medullary and Papillary Thyroid Cancer Cells מאת Hans H G Verbeek, Maria M. Alves, Jan‐Willem B. de Groot, Jan Osinga, John Th. M. Plukker, Thera P. Links, Robert M.W. Hofstra

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Medullary Thyroid Cancer in the Era of Tyrosine Kinase Inhibitors: To Treat or Not to Treat—and With Which Drug—Those Are the Questions מאת Maria E. Cabanillas, Mimi I. Hu, Camilo Jiménez

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AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs מאת Catherine Wilson, Xiaofen Ye, Thinh Pham, Eva Lin, Sara M. Chan, Erin McNamara, Richard M. Neve, Lisa D. Belmont, Hartmut Koeppen, Robert L. Yauch, Avi Ashkenazi, Jeff Settleman

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The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer מאת Carina Hage, Vanessa Rausch, Nathalia A. Giese, Thomas Giese, Frank Schönsiegel, Sabrina Labsch, Clifford C. Nwaeburu, J Mattern, Jury Gladkich, Ingrid Herr

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In the clinic: ongoing clinical trials evaluating c-MET-inhibiting drugs מאת Neelesh Sharma, Alex A. Adjei

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Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma מאת Nathalène Truffaux, Cathy Philippe, Janna Paulsson, Felipe Andreiuolo, Léa Guerrini‐Rousseau, Gaétan Cornilleau, Ludivine Le Dret, Catherine Richon, Ludovic Lacroix, Stéphanie Puget, Birgit Geoerger, Gilles Vassal, Arne Östman, Jacques Grill

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