Insulation between adjacent TADs is controlled by the width of their boundaries through distinct mechanisms
Topologically associating domains (TADs) are sub-Megabase regions in vertebrate genomes with enriched intradomain interactions that restrict enhancer-promoter contacts across their boundaries. However, the mechanisms that separate TADs remain incompletely understood. Most boundaries between TADs con...
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| Main Authors: | , , , , |
|---|---|
| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2025
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| 在线阅读: | https://doi.org/10.1073/pnas.2413112122 |
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