NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer

NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer

Non-small-cell lung cancer (NSCLC) represents a highly prevalent form of malignancy. 5-methylcytosine (m5C) methylation functions as a key post-transcriptional regulatory mechanism linked to cancer progression. The persistent expression of PD-L1 in tumor cells plays a pivotal role in facilitating im...

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Bibliografske podrobnosti
Main Authors: Yiran Yang, Leiqun Cao, Xin Xu, Dan Li, Yuan Deng, Li Lan, Bingjie Zeng, Haixia Jiang, Shan Liang, Yiwen Huang, Yunhua Xu, Lifang Ma
Format: Artigo
Jezik:angleščina
Izdano: 2025
Online dostop:https://doi.org/10.1007/s00262-025-03986-5
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https://doi.org/10.1007/s00262-025-03986-5

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