GERMLINE PATHOGENIC VARIANTS IN PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA AND EXTRA-PANCREATIC MALIGNANCIES: A NATIONWIDE DATABASE ANALYSIS

GERMLINE PATHOGENIC VARIANTS IN PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA AND EXTRA-PANCREATIC MALIGNANCIES: A NATIONWIDE DATABASE ANALYSIS

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. About 10% of affected individuals have an inherited component. Deleterious germline variants increase the lifetime risk for PDAC and are often associated with an elevated risk for extra-pancreatic malignancies. In this study, we aim to det...

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Hlavní autoři: Valentyna Kryklyva, Michael J. Pflüger, Hicham Ouchene, Hanneke Volleberg-Gorissen, Arjen R. Mensenkamp, Marianne A. Jonker, Carlijn van de Water, Irıs D. Nagtegaal, Marjolijn J. L. Ligtenberg, Lodewijk A.A. Brosens
Médium: Artigo
Jazyk:angličtina
Vydáno: 2025
On-line přístup:https://doi.org/10.1016/j.modpat.2025.100709
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https://doi.org/10.1016/j.modpat.2025.100709

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