Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis

Macrophages play a crucial role in chronic gastritis induced by the pathogenic Helicobacter pylori (H. pylori) infection. NLRP3 inflammasome has emerged as an important component of inflammatory processes. However, the molecular mechanism by which H. pylori infection drives NLRP3 inflammasome and ma...

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Main Authors: Fei Xiao, Sihai Chen, Leyan Li, Xinbo Xu, Huan Wang, Huajing Ke, Cong He, Chuan Xie, Xidong Wu, Jianping Liu, Yong Xie, Nonghua Lü, Yin Zhu, Nianshuang Li
Formato: Artigo
Idioma:inglés
Publicado: 2025
Acceso en liña:https://doi.org/10.1186/s12964-024-02017-7
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