Inhibition of Glutaminase 1 Reduces M1 Macrophage Polarization to Protect Against Monocrotaline-Induced Pulmonary Arterial Hypertension

(1) BACKGROUND: Metabolic abnormalities and immune inflammation are key elements within pathogenesis of pulmonary arterial hypertension (PAH). And in PAH patients, aberrant glutamine metabolism has been observed; however, the function of glutaminase 1 (GLS1) in macrophage is still unknown. So we aim...

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Main Authors: Xing Chen, Lixiang Li, Yan Deng, Juan Liao, Hui Meng, Limei Liang, Jie Hu, Dongwei Xie, G Liang
格式: Artigo
語言:英语
出版: 2025
在線閱讀:https://doi.org/10.1016/j.imlet.2025.106974
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