Indirect suppression of CD4 T cell activation through LAG-3-mediated trans-endocytosis of MHC class II
Blockade of immune checkpoint receptors has shown outstanding efficacy for tumor immunotherapy. Promising treatment with anti-lymphocyte-activation gene-3 (LAG-3) has already been recognized as the next efficacious treatment, but there is still limited understanding of the mechanism of LAG-3-mediate...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2024
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| Acesso em linha: | https://doi.org/10.1016/j.celrep.2024.114655 |
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