Indirect suppression of CD4 T cell activation through LAG-3-mediated trans-endocytosis of MHC class II

Indirect suppression of CD4 T cell activation through LAG-3-mediated trans-endocytosis of MHC class II

Blockade of immune checkpoint receptors has shown outstanding efficacy for tumor immunotherapy. Promising treatment with anti-lymphocyte-activation gene-3 (LAG-3) has already been recognized as the next efficacious treatment, but there is still limited understanding of the mechanism of LAG-3-mediate...

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Bibliographic Details
Main Authors: Ei Wakamatsu, Hiroaki Machiyama, Hiroko Toyota, Arata Takeuchi, Ryuji Hashimoto, Haruo Kozono, Tadashi Yokosuka
Format: Artigo
Language:English
Published: 2024
Online Access:https://doi.org/10.1016/j.celrep.2024.114655
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https://doi.org/10.1016/j.celrep.2024.114655

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