Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium

Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium

Acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL-2, creating a therapeutic opportunity to target LSCs using the BCL-2 inhibitor venetoclax. Although venetoclax-based regimens have sho...

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Autors principals: Anagha Inguva, Mark J. Althoff, Hunter Tolison, Krysta L. Engel, Maria L. Amaya, Anna E. Krug, Tracy N. Young, Mohammad Minhajuddin, Shanshan Pei, Sweta B. Patel, Amanda Winters, Regan Miller, Ian T. Shelton, Jonathan St‐Germain, Tianyi Ling, Courtney L. Jones, Brian Raught, Austin E. Gillen, Monica Ransom, Sarah Staggs, Clayton A. Smith, Daniel A. Pollyea, Brett M. Stevens, Craig T. Jordan
Format: Artigo
Idioma:anglès
Publicat: 2024
Accés en línia:https://doi.org/10.1158/2159-8290.cd-23-1145
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https://doi.org/10.1158/2159-8290.cd-23-1145

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