Long somatic DNA-repeat expansion drives neurodegeneration in Huntington disease

Long somatic DNA-repeat expansion drives neurodegeneration in Huntington disease

Abstract Huntington Disease (HD) is a fatal genetic disease in which most striatal projection neurons (SPNs) degenerate. The central biological question about HD pathogenesis has been how the disease-causing DNA repeat expansion (CAG n ) in the huntingtin ( HTT ) gene leads to neurodegeneration afte...

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Hlavní autoři: Robert E. Handsaker, Seva Kashin, Nora Reed, Steven Tan, Won‐Seok Lee, Tara M. McDonald, Kiely Morris, Nolan Kamitaki, Christopher D. Mullally, Neda R. Morakabati, Melissa Goldman, Gabriel Lind, Rhea Kohli, Elisabeth Lawton, Marina Hogan, Kiku Ichihara, Sabina Berretta, Steven A. McCarroll
Médium: Pré-impressão
Jazyk:angličtina
Vydáno: 2024
On-line přístup:https://doi.org/10.1101/2024.05.17.592722
https://www.biorxiv.org/content/biorxiv/early/2024/05/20/2024.05.17.592722.full.pdf
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https://doi.org/10.1101/2024.05.17.592722
https://www.biorxiv.org/content/biorxiv/early/2024/05/20/2024.05.17.592722.full.pdf

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