Long somatic DNA-repeat expansion drives neurodegeneration in Huntington disease
Abstract Huntington Disease (HD) is a fatal genetic disease in which most striatal projection neurons (SPNs) degenerate. The central biological question about HD pathogenesis has been how the disease-causing DNA repeat expansion (CAG n ) in the huntingtin ( HTT ) gene leads to neurodegeneration afte...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| 格式: | Pré-impressão |
| 語言: | 英语 |
| 出版: |
2024
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| 在線閱讀: | https://doi.org/10.1101/2024.05.17.592722 https://www.biorxiv.org/content/biorxiv/early/2024/05/20/2024.05.17.592722.full.pdf |
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