Protective role for kidney TREM2 macrophages in obesity- and diabetes-induced kidney injury

Protective role for kidney TREM2 macrophages in obesity- and diabetes-induced kidney injury

Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profiles from DKD patients and two DKD mouse models at multiple ti...

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Glavni autori: Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Carlos Arevalo, Fan Zhang, Michal Slyper, Julia Waldman, Mónica S. Montesinos, Danielle Dionne, Lan Nguyễn, Michael S. Cuoco, Dan Dubinsky, Jason Q. Purnell, Keith Keller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, A. Kötek, Giorgio Trivioli, Nathan Richoz, Mary Beth Humphrey, Isabella G. Darby, Sarah J. Miller, Yingping Xu, Astrid Weins, Alexandra Chloe-Villani, Steven L. Chang, Matthias Kretzler, Orit Rosenblatt-Rosen, Jillian L. Shaw, Kurt A. Zimmerman, Menna R. Clatworthy, Aviv Regev, Anna Greka
Format: Artigo
Jezik:engleski
Izdano: 2024
Online pristup:https://doi.org/10.1016/j.celrep.2024.114253
https://www.cell.com/article/S2211124724005813/pdf
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https://doi.org/10.1016/j.celrep.2024.114253
https://www.cell.com/article/S2211124724005813/pdf

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