185P Safety, tolerability, and antitumor activity of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2+ metastatic breast cancer (mBC) and active brain metastases (BM) in DESTINY-Breast07 (DB-07)

185P Safety, tolerability, and antitumor activity of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2+ metastatic breast cancer (mBC) and active brain metastases (BM) in DESTINY-Breast07 (DB-07)

DEBBRAH, ROSET-BM, TUXEDO-1, and a pooled DB-01, -02, -03 analysis indicate robust efficacy of T-DXd in pts with stable/active BM; however, efficacy in pts with BM is not yet fully established. DB-07 is a phase Ib/II, multicenter, open-label study exploring the safety, tolerability, and antitumor ac...

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Main Authors: C. Anders, S. Loi, Erika Hamilton, Komal Jhaveri, P. Schmid, Erhan Gökmen, S-A. Im, Cengiz Karaçin, Carlos H. Barrios, Y.H. Park, S. Uzunoğlu, Sarah E. Boston, Adam Konpa, S. Mondal, Fabrice André
Format: Artigo
Language:English
Published: 2024
Online Access:https://doi.org/10.1016/j.esmoop.2024.103207
http://www.esmoopen.com/article/S205970292400975X/pdf
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https://doi.org/10.1016/j.esmoop.2024.103207
http://www.esmoopen.com/article/S205970292400975X/pdf

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