SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes
Pancreatic β-cell dysfunction is a key feature of type 2 diabetes, and novel regulators of insulin secretion are desirable. Here we report that the succinate receptor (SUCNR1) is expressed in β-cells and is up-regulated in hyperglycemic states in mice and humans. We found that succinate acts as a ho...
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2024
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| On-line přístup: | https://doi.org/10.1172/jci173214 http://www.jci.org/articles/view/173214/files/pdf |
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