Blood brain barrier disruption and glutamatergic excitotoxicity in post-acute sequelae of SARS COV-2 infection cognitive impairment: potential biomarkers and a window into pathogenesis

Objective To investigate the association between blood–brain barrier permeability, brain metabolites, microstructural integrity of the white matter, and cognitive impairment (CI) in post-acute sequelae of SARS-COV-2 infection (PASC). Methods In this multimodal longitudinal MRI study 14 PASC particip...

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Main Authors: Joga Chaganti, Govinda Poudel, Lucette A. Cysique, Gregory J. Dore, Anthony D. Kelleher, Gael Matthews, D.R. Darley, Anthony Byrne, David Jakabek, Xin Zhang, Marrissa Lewis, Nikhil Jha, Bruce J. Brew
Format: Artigo
Language:English
Published: 2024
Online Access:https://doi.org/10.3389/fneur.2024.1350848
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1350848/pdf
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