VDAC1-interacting molecules promote cell death in cancer organoids through mitochondrial-dependent metabolic interference

VDAC1-interacting molecules promote cell death in cancer organoids through mitochondrial-dependent metabolic interference

The voltage-dependent anion-selective channel isoform 1 (VDAC1) is a pivotal component in cellular metabolism and apoptosis with a prominent role in many cancer types, offering a unique therapeutic intervention point. Through an

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Bibliografiska uppgifter
Huvudupphovsmän: Stefano Conti Nibali, Silvia De Siervi, Enrico Luchinat, Andrea Magrì, Angela Messina, Lorenza Brocca, Stefania Mantovani, Barbara Oliviero, Mario U. Mondelli, Vito De Pinto, Cristian Turato, Cristina Arrigoni, Marco Lolicato
Materialtyp: Artigo
Språk:engelska
Publicerad: 2024
Länkar:https://doi.org/10.1016/j.isci.2024.109853
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Sammanfattning:The voltage-dependent anion-selective channel isoform 1 (VDAC1) is a pivotal component in cellular metabolism and apoptosis with a prominent role in many cancer types, offering a unique therapeutic intervention point. Through an

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