<i>MC4R</i> variants modulate α-MSH and setmelanotide induced cellular signaling at multiple levels

<i>MC4R</i> variants modulate α-MSH and setmelanotide induced cellular signaling at multiple levels

Abstract Context The melanocortin-4 receptor (MC4R) plays an important role in body weight regulation. Pathogenic MC4R variants are the most common cause of monogenic obesity. Objective We have identified 17 MC4R variants in adult and pediatric patients with obesity. Here we aimed to functionally ch...

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Hlavní autoři: Alejandra Virginia Rodriguez Rondon, Mila S. Welling, Erica L T van den Akker, Elisabeth F. C. van Rossum, Elles M. J. Boon, Mieke M. van Haelst, Patric J. D. Delhanty, Jenny A. Visser
Médium: Artigo
Jazyk:angličtina
Vydáno: 2024
On-line přístup:https://doi.org/10.1210/clinem/dgae210
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https://doi.org/10.1210/clinem/dgae210

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