Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease
Originally developed as a chemotherapeutic agent, miltefosine (hexadecylphosphocholine) is an inhibitor of phosphatidylcholine synthesis with proven antiparasitic effects. It is the only oral drug approved for the treatment of Leishmaniasis and American Trypanosomiasis (Chagas disease). Although its...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2024
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| On-line přístup: | https://doi.org/10.3390/biom14040406 https://www.mdpi.com/2218-273X/14/4/406/pdf?version=1711540530 |
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