The <i>Abca7<sup>V1613M</sup></i> variant reduces Aβ generation, plaque load, and neuronal damage

The <i>Abca7<sup>V1613M</sup></i> variant reduces Aβ generation, plaque load, and neuronal damage

Abstract BACKGROUND Variants in ABCA7 , a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer's disease (LOAD). METHODS CRISPR‐Cas9 was used to generate an Abca7 V1613M variant in mice, modeling the homologous human ABCA7 V1599...

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Hlavní autoři: Claire A. Butler, Adrian Mendoza Arvilla, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Narges Rezaie, Heidi Yahan Liang, Dominic I. Javonillo, Annie Thach, Shuling Wang, Sherilyn Collins, Amber Walker, Kai‐Xuan Shi, Jonathan Neumann, Ángela Gómez-Arboledas, Caden M. Henningfield, Lindsay A. Hohsfield, Mark Mapstone, Andrea J. Tenner, Frank M. LaFerla, A Mortazavi, Grant R. MacGregor, Kim N. Green
Médium: Artigo
Jazyk:angličtina
Vydáno: 2024
On-line přístup:https://doi.org/10.1002/alz.13783
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13783
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https://doi.org/10.1002/alz.13783
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13783

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