A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

Abstract Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. However, the determination of TM-interconnectivity in individual tumors is challenging and the impact on patient survival unresolved. Here, we establish a conne...

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Główni autorzy: Ling Hai, Dirk C. Hoffmann, Robin J. Wagener, Daniel Domínguez Azorín, David Hausmann, Ruifan Xie, Magnus-Carsten Huppertz, Julien Hiblot, Philipp Sievers, Sophie Heuer, Jakob Ito, Gina Cebulla, Alexandros Kourtesakis, Leon D. Kaulen, Miriam Ratliff, Henriette Mandelbaum, Erik Jung, Ammar Jabali, Sandra Horschitz, Kati Ernst, Denise Reibold, Uwe Warnken, Varun Venkataramani, Rainer Will, Mario L. Suvà, Christel Herold‐Mende, Felix Sahm, Frank Winkler, Matthias Schlesner, Wolfgang Wick, Tobias Keßler
Format: Artigo
Język:angielski
Wydane: 2024
Dostęp online:https://doi.org/10.1038/s41467-024-45067-8
https://www.nature.com/articles/s41467-024-45067-8.pdf
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https://doi.org/10.1038/s41467-024-45067-8
https://www.nature.com/articles/s41467-024-45067-8.pdf

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