Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease

Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease

Abstract This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking behaviors, smoking-related DNA methylation and the r...

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Main Authors: Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou, Alex Adams, Alexandra Noble, Nicholas T. Ventham, Judith Wellens, Gwo–Tzer Ho, Malcolm G. Dunlop, Jan Krzysztof Nowak, Yuan Ding, Zhanju Liu, Jack Satsangi, Evropi Τheodoratou, Xue Li
Format: Artigo
Language:English
Published: 2024
Online Access:https://doi.org/10.1038/s41467-024-44841-y
https://www.nature.com/articles/s41467-024-44841-y.pdf
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https://doi.org/10.1038/s41467-024-44841-y
https://www.nature.com/articles/s41467-024-44841-y.pdf

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