Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina

Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina

Decades of biological and clinical research have led to important advances in recombinant adeno-associated viruses rAAV-based gene therapy gene therapy. However, several challenges must be overcome to fully exploit the potential of rAAV vectors. Innovative approaches to modify viral genome and capsi...

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Hlavní autoři: Aurélien Leray, Pierre-Alban Lalys, Juliette Varin, Mohammed Bouzelha, Audrey Bourdon, Dimitri Álvarez‐Dorta, Karine Pavageau, Sébastien Depienne, Maia Marchand, Anthony Mellet, Joanna Demilly, Jean‐Baptiste Ducloyer, Tiphaine Girard, B. Fraysse, Mireille Ledevin, Mickaël Guilbaud, Sébastien G. Gouin, Eduard Ayuso, Oumeya Adjali, Thibaut Larcher, Thérèse Cronin, Caroline Le Guiner, David Deniaud, Mathieu Mével
Médium: Artigo
Jazyk:angličtina
Vydáno: 2024
On-line přístup:https://doi.org/10.1016/j.biopha.2024.116148
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https://doi.org/10.1016/j.biopha.2024.116148

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