Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

The emergence of Omicron lineages and descendent subvariants continues to present a severe threat to the effectiveness of vaccines and therapeutic antibodies. We have previously suggested that an insufficient mucosal immunoglobulin A (IgA) response induced by the mRNA vaccines is associated with a s...

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Main Authors: Harold Marcotte, Yunlong Cao, Fanglei Zuo, Luca Simonelli, José Camilla Sammartino, Mattia Pedotti, Rui Sun, Irene Cassaniti, Marie Hagbom, Antonio Piralla, Jin‐Xuan Yang, Likun Du, Elena Percivalle, Federico Bertoglio, Maren Schubert, Hassan Abolhassani, Natalia Sherina, Concetta Guerra, Stephan Borte, Nima Rezaei, Makiko Kumagai‐Braesch, Yintong Xue, Chen Su, Qihong Yan, Ping He, Caroline Grönwall, Lars Klareskog, Luigi Calzolai, Andrea Cavalli, Qiao Wang, Davide F. Robbiani, Michael Hust, Zheng‐Li Shi, Liqiang Feng, Lennart Svensson, Ling Chen, Linlin Bao, Fausto Baldanti, Junyu Xiao, Chuan Qin, Lennart Hammarström, Xing‐Lou Yang, Luca Varani, Xiaoliang Sunney Xie, Qiang Pan‐Hammarström
格式: Artigo
语言:英语
出版: 2024
在线阅读:https://doi.org/10.1073/pnas.2315354120
https://www.pnas.org/doi/pdf/10.1073/pnas.2315354120
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https://doi.org/10.1073/pnas.2315354120
https://www.pnas.org/doi/pdf/10.1073/pnas.2315354120

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