A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

SUMMARY Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage with complex inter- and intra-tumoral heterogeneity. To chart this complexity, we generated a comprehensive cell atlas of 55 neuroblastoma patient tumors, collected from two pediatric cancer institutions,...

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Main Authors: Anand G. Patel, Orr Ashenberg, Natalie B. Collins, Åsa Segerstolpe, Sizun Jiang, Michal Slyper, Xin Huang, Chiara Caraccio, Hongjian Jin, Heather Sheppard, Ke Xu, Ti‐Cheng Chang, Brent A. Orr, Abbas Shirinifard, Richard H. Chapple, Amber Shen, Michael R. Clay, Ruth Tatevossian, Colleen Reilly, Jaimin Patel, Marybeth Lupo, Cynthia Cline, Danielle Dionne, Caroline Porter, Julia Waldman, Yunhao Bai, Bokai Zhu, Irving Barrera, Evan Murray, Sébastien Vigneau, Sara Napolitano, Isaac Wakiro, Jingyi Wu, Grace Grimaldi, Laura DelloStritto, Karla Helvie, Asaf Rotem, Ana Lako, Nicole Cullen, Kathleen L. Pfaff, Åsa Karlström, Judit Jané‐Valbuena, Ellen Todres, Aaron R. Thorner, Paul Geeleher, Scott J. Rodig, Xin Zhou, Elizabeth Stewart, Bruce E. Johnson, Gang Wu, Fei Chen, Jiyang Yu, Yury Goltsev, Garry P. Nolan, Orit Rozenblatt–Rosen, Aviv Regev, Michael A. Dyer
Format: Pré-impressão
Language:English
Published: 2024
Online Access:https://doi.org/10.1101/2024.01.07.574538
https://www.biorxiv.org/content/biorxiv/early/2024/01/16/2024.01.07.574538.full.pdf
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https://doi.org/10.1101/2024.01.07.574538
https://www.biorxiv.org/content/biorxiv/early/2024/01/16/2024.01.07.574538.full.pdf

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