In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis

Metabolons are protein assemblies that perform a series of reactions in a metabolic pathway. However, the general importance and aptitude of metabolons for enzyme catalysis remain poorly understood. In animals, biosynthesis of coenzyme Q is currently attributed to ten different proteins, with COQ3,...

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Bibliographic Details
Main Authors: Callum R. Nicoll, Laura Alvigini, Andrea Gottinger, Domiziana Cecchini, Barbara Mannucci, Federica Corana, María Laura Mascotti, Andrea Mattevi
Format: Artigo
Language:English
Published: 2024
Online Access:https://doi.org/10.1038/s41929-023-01087-z
https://www.nature.com/articles/s41929-023-01087-z.pdf
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