IKZF1 Alterations and Therapeutic Targeting in B-Cell Acute Lymphoblastic Leukemia
IKZF1 encodes the transcription factor IKAROS, a zinc finger DNA-binding protein with a key role in lymphoid lineage development. IKAROS plays a critical role in the development of lineage-restricted mature lymphocytes. Deletions within IKZF1 in B-cell acute lymphoblastic leukemia (B-ALL) lead to a...
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| Main Authors: | , , , |
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| Formato: | Revisão |
| Idioma: | Inglês |
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2024
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| Acesso em linha: | https://doi.org/10.3390/biomedicines12010089 https://www.mdpi.com/2227-9059/12/1/89/pdf?version=1704094659 |
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