Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy
CD47 and its receptor signal regulatory protein α (SIRPα) act as a dominant antiphagocytic, "don't eat me" signal. Recent studies reveal CD24 as a novel target for cancer immunotherapy by macrophages in ovarian cancer and breast cancer. However, whether simultaneous blockade of CD47 a...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2023
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| Online Access: | https://doi.org/10.1016/j.omto.2023.100747 https://www.cell.com/article/S2372770523000967/pdf |
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