The structural mechanism of dimeric DONSON in replicative helicase activation

The structural mechanism of dimeric DONSON in replicative helicase activation

The MCM motor of the replicative helicase is loaded onto origin DNA as an inactive double hexamer before replication initiation. Recruitment of activators GINS and Cdc45 upon S-phase transition promotes the assembly of two active CMG helicases. Although work with yeast established the mechanism for...

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Hlavní autoři: Milos A. Cvetkovic, Paolo Passaretti, Agata Butryn, Alicja Reynolds-Winczura, Georgia Kingsley, Aggeliki Skagia, Cyntia Fernandez-Cuesta, Divyasree Poovathumkadavil, Roger George, Anoop Singh Chauhan, Satpal S. Jhujh, Grant S. Stewart, Agnieszka Gambus, Alessandro Costa
Médium: Artigo
Jazyk:angličtina
Vydáno: 2023
On-line přístup:https://doi.org/10.1016/j.molcel.2023.09.029
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https://doi.org/10.1016/j.molcel.2023.09.029

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