PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation

Abstract Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disorder of the central nervous system (CNS). Current therapies mainly target inflammatory processes during acute stages, but effective treatments for progressive MS are limited. In this context, astrocytes have gained increasing...

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Main Authors: Mathias Linnerbauer, Tobias A. Beyer, Lucy Nirschl, Daniel Farrenkopf, Lena Lößlein, Oliver Vandrey, Anne Peter, Thanos Tsaktanis, Hania Kébir, David Laplaud, Rupert Oellinger, Thomas Engleitner, Jorge I. Alvarez, Roland Rad, Thomas Korn, Bernhard Hemmer, Francisco J. Quintana, Veit Rothhammer
格式: Artigo
语言:英语
出版: 2023
在线阅读:https://doi.org/10.1038/s41467-023-40982-8
https://www.nature.com/articles/s41467-023-40982-8.pdf
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