Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy

Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy

Proofreading (editing) of mischarged tRNAs by cytoplasmic aminoacyl-tRNA synthetases (aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high significance for protein homeostasis. However, whether mitochondrial translation needs fidelity and the significance of editing by...

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Bibliográfalaš dieđut
Váldodahkkit: Wen-Qiang Zheng, Jianhui Zhang, Zi-Han Li, Xiuxiu Liu, Yong Zhang, Shuo Huang, Jinsong Li, Bin Zhou, Gilbert Eriani, En‐Duo Wang, Xiao-Long Zhou
Materiálatiipa: Artigo
Giella:eaŋgalasgiella
Almmustuhtton: 2023
Liŋkkat:https://doi.org/10.1073/pnas.2309714120
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https://doi.org/10.1073/pnas.2309714120

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