The difficulty of aligning intrinsically disordered protein sequences as assessed by conservation and phylogeny

Intrinsically disordered proteins (IDPs) are proteins that lack a stable 3D structure but maintain a biological function. It has been frequently suggested that IDPs are difficult to align because they tend to have fewer conserved residues compared to ordered proteins, but to our knowledge this has n...

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Hlavní autoři: Andrew C. Riley, Daniel Ashlock, Steffen P. Graether
Médium: Artigo
Jazyk:angličtina
Vydáno: 2023
On-line přístup:https://doi.org/10.1371/journal.pone.0288388
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288388&type=printable
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