Effect of the <scp>glucagon‐like</scp> peptide‐1 receptor agonist liraglutide, compared to caloric restriction, on appetite, dietary intake, body fat distribution and cardiometabolic biomarkers: A randomized trial in adults with obesity and prediabetes

To investigate the hypothesis that weight loss with the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide alone would lead to a greater reduction in the proportion of fat to lean tissue mass when compared to caloric restriction (CR) alone, as well as when compared to treatment with sita...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Heidi J. Silver, Dianna Olson, Dustin Mayfield, Patricia A. Wright, Hui Nian, Mona Mashayekhi, John R. Koethe, Kevin D. Niswender, James M. Luther, Nancy J. Brown
Μορφή: Artigo
Γλώσσα:Αγγλικά
Έκδοση: 2023
Διαθέσιμο Online:https://doi.org/10.1111/dom.15113
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Περιγραφή
Περίληψη:To investigate the hypothesis that weight loss with the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide alone would lead to a greater reduction in the proportion of fat to lean tissue mass when compared to caloric restriction (CR) alone, as well as when compared to treatment with sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, that also enhances GLP-1 activity - to determine the independent effects of each treatment.