Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis

Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with ursodeoxycholic acid (UDCA) as first-line treatment. Poor response to UDCA is associated with a higher risk of progressing to cirrhosis, but the underlying mechanisms are unclear. UDCA modulates the composition of primary...

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Main Authors: Laura Martinez‐Gili, Alexandros Pechlivanis, Julie A. K. McDonald, Sofina Begum, Jonathan Badrock, Jessica Dyson, Rebecca Jones, Gideon M. Hirschfield, Stephen Ryder, Richard Sandford, Simon Rushbrook, Douglas Thorburn, Simon D. Taylor‐Robinson, Mary M.E. Crossey, Julian R. Marchesi, George Mells, Elaine Holmes, David Jones
Format: Artigo
Language:English
Published: 2023
Online Access:https://doi.org/10.1080/19490976.2023.2208501
https://www.tandfonline.com/doi/pdf/10.1080/19490976.2023.2208501?needAccess=true&role=button
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https://doi.org/10.1080/19490976.2023.2208501
https://www.tandfonline.com/doi/pdf/10.1080/19490976.2023.2208501?needAccess=true&role=button

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