A dual-action niclosamide-based prodrug that targets cancer stem cells and inhibits TNBC metastasis

A dual-action niclosamide-based prodrug that targets cancer stem cells and inhibits TNBC metastasis

Chemotherapy typically destroys the tumor mass but rarely eradicates the cancer stem cells (CSCs) that can drive metastatic recurrence. A key current challenge is finding ways to eradicate CSCs and suppress their characteristics. Here, we report a prodrug, Nic-A, created by combining a carbonic anhy...

Saved in:

書目詳細資料
Main Authors:	Ji Hyeon Kim, Soeun Park, Eunsun Jung, Jin Woo Shin, Yoon-Jae Kim, Ji Young Kim, Jonathan L. Sessler, Jae Hong Seo, Jong Seung Kim
格式:	Artigo
語言:	英语
出版:	2023
在線閱讀:	https://doi.org/10.1073/pnas.2304081120
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

相似書籍

Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51
由: Lee, Jung Ok, et al.
出版: (2019)

Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51
由: Jung Ok Lee, et al.
出版: (2019)

Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres
由: Oh, Hyeong-Cheol, et al.
出版: (2020)

Comparisons of Oncologic Outcomes between Triple-Negative Breast Cancer (TNBC) and Non-TNBC among Patients Treated with Breast-Conserving Therapy
由: Kim, Sanghwa, et al.
出版: (2016)

Bioanalysis of niclosamide in plasma using liquid chromatography-tandem mass and application to pharmacokinetics in rats and dogs
由: Choi, Hae-In, et al.
出版: (2021)

Investigation of niclosamide as a repurposing agent for skeletal muscle atrophy
由: Kim, Hyun-Jun, et al.
出版: (2021)

Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer
由: Kang, Hee Eun, et al.
出版: (2021)

EXTH-23. COMBINED EFFECTS OF NICLOSAMIDE AND TEMOZOLOMIDE AGAINST HUMAN GLIOBLASTOMA TUMORSPHERES
由: Cheol Oh, Hyeong, et al.
出版: (2019)

Erratum: Correction of Author’s name in the Article “Sex-Specific Trends in the Prevalence of Hypertension and the Number of People With Hypertension: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 1998–2018”
由: Seo, Eunsun, et al.
出版: (2022)

Fluorogenic Reaction-Based Prodrug Conjugates as Targeted Cancer Theranostics
由: Lee, Min Hee, et al.
出版: (2018)

Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness
由: So‐Yeon Park, et al.
出版: (2018)

Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3
由: Ahn, Sung Yong, et al.
出版: (2017)

Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug
由: Amit Sharma, et al.
出版: (2018)

Anticancer Effect of Benzimidazole Derivatives, Especially Mebendazole, on Triple-Negative Breast Cancer (TNBC) and Radiotherapy-Resistant TNBC In Vivo and In Vitro
由: Choi, Hoon Sik, et al.
出版: (2021)

Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases
由: Hwang, Soeun, et al.
出版: (2021)

Small molecule activator of Nm23/NDPK as an inhibitor of metastasis
由: Lee, Jae-Jin, et al.
出版: (2018)

Thought-Action Fusion as Predictors of Obsessive-Compulsive Symptom Dimensions
由: Kim, Ji Eun, et al.
出版: (2020)

Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction
由: Ahn, Sung Yong, et al.
出版: (2017)

Comparison of Computed Tomography-based Abdominal Adiposity Indexes as Predictors of Non-alcoholic Fatty Liver Disease Among Middle-aged Korean Men and Women
由: Baek, Jongmin, et al.
出版: (2020)

The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced Drosophila Model of Peripheral Neuropathy
由: Jang, Hye-Ji, et al.
出版: (2022)

The magic bullet: Niclosamide
由: Haowen Jiang, et al.
出版: (2022)

Comparison of Real-Time and Intermittently-Scanned Continuous Glucose Monitoring for Glycemic Control in Type 1 Diabetes Mellitus: Nationwide Cohort Study
由: Ji Yoon Kim, et al.
出版: (2025)

Niclosamide exerts anticancer effects through inhibition of the FOXM1-mediated DNA damage response in prostate cancer
由: Kim, Mee Young, et al.
出版: (2021)

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
由: Yun, Jeong Mi, et al.
出版: (2018)

Association Between Parity and Low Bone Density Among Postmenopausal Korean Women
由: Seo, Eunsun, et al.
出版: (2021)

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics
由: N. Sanoj Rejinold, et al.
出版: (2025)

Hepatocellular Carcinoma Presenting as Uterine Metastasis
由: Kang, Woo Dae, et al.
出版: (2008)

Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death
由: So-Jung Park, et al.
出版: (2011)

MBRS-56. RE-EVALUATION OF LEPTOMENINGEAL METASTASIS IN MEDULLOBLASTOMA WITH MAGNETIC RESONANCE IMAGING, RELATED SYMPTOMS AND CEREBROSPINAL FLUID METABOLOMIC PROFILES
由: Im, Ji Hye, et al.
出版: (2020)

Niclosamide and Pyrvinium Are Both Potential Therapeutics for Osteosarcoma, Inhibiting Wnt–Axin2–Snail Cascade
由: Yi, Young, et al.
出版: (2021)

Development of an Efficient Dual‐Action GST‐Inhibiting Anticancer Platinum(IV) Prodrug
由: Keefe Guang Zhi Lee, et al.
出版: (2018)

RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC
由: Seong‐Jin Kim, et al.
出版: (2020)

Niclosamide: Beyond an antihelminthic drug
由: Chen, Wei, et al.
出版: (2018)

Niclosamide: Beyond an antihelminthic drug
由: Wei Chen, et al.
出版: (2017)

The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling
由: Chen, Minyong, et al.
出版: (2009)

The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling
由: Minyong Chen, et al.
出版: (2009)

Cripto-1 in TNBC
由: Castro, Nadia P, et al.
出版: (2015)

GHRH-antagonists in TNBC
由: Engel, Jörg B.
出版: (2015)

Design and synthesis of vidarabine prodrugs as antiviral agents
由: Shen, Wei, et al.
出版: (2008)

Pre-Clinical Pharmacokinetic Characterization, Tissue Distribution, and Excretion Studies of Novel Edaravone Oral Prodrug, TEJ-1704
由: Kang, Dong Wook, et al.
出版: (2021)