<i>TP53</i> Gain-of-Function and Non–Gain-of-Function Mutations Are Associated With Differential Prognosis in Advanced Pancreatic Ductal Adenocarcinoma

<i>TP53</i> Gain-of-Function and Non–Gain-of-Function Mutations Are Associated With Differential Prognosis in Advanced Pancreatic Ductal Adenocarcinoma

PURPOSE To examine the impact of TP53 gain-of-function (GOF) and non-GOF mutations on prognosis of advanced pancreatic ductal adenocarcinoma (PDAC) among patients with KRAS, CDKN2A, and SMAD4 comutations. METHODS This cohort included patients with locally advanced, recurrent, and de novo metastatic...

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Main Authors: Minggui Pan, Chen Jiang, Zheyang Zhang, Ninah Achacoso, Stacey E. Alexeeff, Aleyda V. Solorzano, Pam Tse, Elaine Chung, Tilak Sundaresan, Jennifer M. Suga, Sachdev Thomas, Laurel A. Habel
Format: Artigo
Language:English
Published: 2023
Online Access:https://doi.org/10.1200/po.22.00570
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https://doi.org/10.1200/po.22.00570

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