BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients: Targeted AAV vector delivery and PET imaging
Intracerebral vector delivery in nonhuman primates has been a major challenge. We report successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson’s disease using low-intensity focus ultrasound in adult macaque mon...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2023
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| 在线阅读: | https://doi.org/10.1126/sciadv.adf4888 https://www.science.org/doi/pdf/10.1126/sciadv.adf4888?download=true |
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