BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients: Targeted AAV vector delivery and PET imaging

BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients: Targeted AAV vector delivery and PET imaging

Intracerebral vector delivery in nonhuman primates has been a major challenge. We report successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson’s disease using low-intensity focus ultrasound in adult macaque mon...

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Hlavní autoři: Javier Blesa, José A. Pineda‐Pardo, Ken‐ichi Inoue, Carmen Gasca‐Salas, Tiziano Balzano, Natalia López‐González del Rey, Alejandro Reinares-Sebastián, Noelia Esteban‐Garcia, Rafael Rodríguez‐Rojas, Raquel Pérez Márquez, María Ciorraga, Marta del Álamo, L. García-Cañamaque, Santiago Ruiz de Aguiar, Itay Rachmilevitch, Inés Trigo‐Damas, Masahiko Takada, José Á. Obeso
Médium: Artigo
Jazyk:angličtina
Vydáno: 2023
On-line přístup:https://doi.org/10.1126/sciadv.adf4888
https://www.science.org/doi/pdf/10.1126/sciadv.adf4888?download=true
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https://doi.org/10.1126/sciadv.adf4888
https://www.science.org/doi/pdf/10.1126/sciadv.adf4888?download=true

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