The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1
Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan metabolizing enzyme chronically activated in many cancer patients and its expression and activity correlate with a poor prognosis. In fact, it acts as an immune regulator and contributes to tumor-induced immunosuppression by determining tryptophan...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2023
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| On-line přístup: | https://doi.org/10.3389/fimmu.2023.1134551 https://www.frontiersin.org/articles/10.3389/fimmu.2023.1134551/pdf |
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