Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration

Sustained release of bioactive BMP2 (bone morphogenetic protein-2) is important for bone regeneration, while the intrinsic short half-life of BMP2 at protein level cannot meet the clinical need. In this study, we aimed to design Bmp2 mRNA-enriched engineered exosomes, which were then loaded into spe...

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Main Authors: Zhujun Yang, Xuejian Li, Xueqi Gan, Mengying Wei, Chunbao Wang, Guodong Yang, Yimin Zhao, Zhuoli Zhu, Zhongshan Wang
Formato: Artigo
Idioma:inglés
Publicado: 2023
Acceso en liña:https://doi.org/10.1186/s12951-023-01871-w
https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-01871-w
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