Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells

Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells

Abstract The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation. Neurotrophin receptors (NTRs) were significantly upregulated in myoepithel...

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Main Authors: Alejandro M. Chibly, Vaishali Patel, Marit H. Aure, Mary C. Pasquale, Robert J. Morell, Daniel Martin Izquierdo, Erich T. Boger, Gemma E. Martin, Mousa Ghannam, Julianne Andrade, Noah G. Denegre, Colleen Simpson, David P. Goldstein, Fei‐Fei Liu, Isabelle M.A. Lombaert, Matthew P. Hoffman
Format: Artigo
Language:English
Published: 2023
Online Access:https://doi.org/10.1038/s41536-023-00290-7
https://www.nature.com/articles/s41536-023-00290-7.pdf
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https://doi.org/10.1038/s41536-023-00290-7
https://www.nature.com/articles/s41536-023-00290-7.pdf

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