Loco-regional treatment with temozolomide-loaded thermogels prevents glioblastoma recurrences in orthotopic human xenograft models

Loco-regional treatment with temozolomide-loaded thermogels prevents glioblastoma recurrences in orthotopic human xenograft models

Glioblastoma multiforme (GBM) is the most aggressive primary tumor of the central nervous system and the diagnosis is often dismal. GBM pharmacological treatment is strongly limited by its intracranial location beyond the blood-brain barrier (BBB). While Temozolomide (TMZ) exhibits the best clinical...

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Main Authors: Lisa Gherardini, Veronica Vetri Buratti, Mirko Maturi, Giovanni Inzalaco, Erica Locatelli, Letizia Sambri, Sara Gargiulo, Virginia Barone, Denise Bonente, Eugenio Bertelli, Silvia Tortorella, Lorenzo Franci, A. Fioravanti, Mauro Comes Franchini, M Chiariello
Formato: Artigo
Idioma:inglés
Publicado: 2023
Acceso en liña:https://doi.org/10.1038/s41598-023-31811-5
https://www.nature.com/articles/s41598-023-31811-5.pdf
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https://doi.org/10.1038/s41598-023-31811-5
https://www.nature.com/articles/s41598-023-31811-5.pdf

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