Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia
Abstract Mitochondrial metabolism recently emerged as a critical dependency in acute myeloid leukemia (AML). The shape of mitochondria is tightly regulated by dynamin GTPase proteins, which drive opposing fusion and fission forces to consistently adapt bioenergetics to the cellular context. Here, we...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2023
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| Online Access: | https://doi.org/10.1038/s41375-023-01835-x https://www.nature.com/articles/s41375-023-01835-x.pdf |
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