Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

Abstract The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here, we report the high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case ( A β PPar...

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Bibliografiset tiedot
Päätekijät: Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew‐Yeu Peak‐Chew, Takashi Saito, Takaomi C. Saido, Jennifer A. Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors H. W. Scheres
Aineistotyyppi: Artigo
Kieli:englanti
Julkaistu: 2023
Linkit:https://doi.org/10.1007/s00401-022-02533-1
https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf
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Internet

https://doi.org/10.1007/s00401-022-02533-1
https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf

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